Fig. 1 · Structure
Documents & Downloads
Pradigastat sodium
DGAT1 Inhibitor
Pradigastat sodium is a selective inhibitor of diacylglyceryl acyltransferase 1 (DGAT1), demonstrating an IC50 value of 0.157 µM. This compound is utilized in research focused on diseases related to abnormal triglyceride metabolism, exhibiting anti-obesity and anti-diabetic properties. Additionally, Pradigastat impacts several transporters, including BCRP, OATP1B1, OATP1B3, and OAT3, with respective IC50 values of 5 µM, 1.66 µM, 3.34 µM, and 0.973 µM. Furthermore, it possesses antiviral activity, effectively inhibiting hepatitis C virus replication in vitro.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 956136-98-4 |
| Applications | DGAT1 Inhibitor |
| Formula | C25H23F3N3NaO2 |
| Molecular Weight | 477.45 |
| Synonyms | LCQ 908 sodium |
| SMILES | O=C(O[Na])C[C@H]1CC[C@H](C2=CC=C(C3=NC=C(NC4=CC=C(C(F)(F)F)N=C4)C=C3)C=C2)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.