Pranlukast-d4 is a deuterated form of Pranlukast, which selectively and competitively antagonizes peptide leukotrienes. This stable isotope demonstrates high potency in inhibiting bindings of [3H]LTE4, [3H]LTD4, and [3H]LTC4 to lung membranes, with inhibition constants of 0.63±0.11 nM, 0.99±0.19 nM, and 5640±680 nM, respectively. Pranlukast-d4 is valuable for pharmacokinetic studies and metabolic profiling in research related to asthma and allergic conditions.
Pranlukast-d4 is a deuterated form of Pranlukast, which selectively and competitively antagonizes peptide leukotrienes. This stable isotope demonstrates high potency in inhibiting bindings of [3H]LTE4, [3H]LTD4, and [3H]LTC4 to lung membranes, with inhibition constants of 0.63±0.11 nM, 0.99±0.19 nM, and 5640±680 nM, respectively. Pranlukast-d4 is valuable for pharmacokinetic studies and metabolic profiling in research related to asthma and allergic conditions.
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