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Biological Activity
Pravastatin sodium is a water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.
Targets
| HMG-CoA reductase | ||||
| 5.6 μM |
| In vitro | DMSO | 79 mg/mL (176.92 mM) | |
| Water | 79 mg/mL (176.92 mM) | ||
| Ethanol | 11 mg/mL (24.63 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.4 mL | 111.98 mL | 223.96 mL |
| 0.5 mM | 4.48 mL | 22.4 mL | 44.79 mL |
| 1 mM | 2.24 mL | 11.2 mL | 22.4 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
*The above data is based on the productmolecular weight 446.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11912 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 81131-70-6 |
| Formula | C23H35NaO7 |
| M. Wt | 446.51 |
| Purity | >98% |
| Synonyms | Eptastatin sodium |
| SMILES | CC[[email protected]](C)C(=O)O[[email protected]]1C[[email protected]@H](C=C2[[email protected]]1[[email protected]]([[email protected]](C=C2)C)CC[[email protected]](C[[email protected]](CC(=O)[O-])O)O)O.[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
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