Fig. 1 · Structure
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Pregnenolone 16α-carbonitrile
PXR Activator
Pregnenolone 16α-carbonitrile is a potent activator of the pregnane X receptor (PXR), primarily utilized in rodent models. As a synthetic steroid, it effectively induces the expression of cytochrome P450 3A, playing a crucial role in drug metabolism. This compound has also been shown to enhance resistance to various stressors, making it valuable for research in pharmacology and toxicology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1434-54-4 |
| Applications | PXR Activator |
| Formula | C22H31NO2 |
| Molecular Weight | 341.49 |
| SMILES | C[C@@]12[C@](C[C@H]([C@@H]2C(C)=O)C#N)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@H](CC4)O)=CC3)C)([H])CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.