Prexasertib mesylate is a selective ATP-competitive inhibitor of checkpoint kinase 1 (CHK1), demonstrating a Ki of 0.9 nM and an IC50 of less than 1 nM. It also inhibits CHK2 and RSK1 with IC50 values of 8 nM and 9 nM, respectively. By inducing double-stranded DNA breaks and triggering replication catastrophe, Prexasertib mesylate leads to apoptosis. Its potent anti-tumor activity makes it valuable for cancer research applications, particularly in studies focusing on DNA damage response and cell cycle regulation.
Prexasertib mesylate is a selective ATP-competitive inhibitor of checkpoint kinase 1 (CHK1), demonstrating a Ki of 0.9 nM and an IC50 of less than 1 nM. It also inhibits CHK2 and RSK1 with IC50 values of 8 nM and 9 nM, respectively. By inducing double-stranded DNA breaks and triggering replication catastrophe, Prexasertib mesylate leads to apoptosis. Its potent anti-tumor activity makes it valuable for cancer research applications, particularly in studies focusing on DNA damage response and cell cycle regulation.
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