Fig. 1 · Structure
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Primordazine B
PAINT Inhibitor
Primordazine B is a selective PAINT inhibitor that targets Poly(A)-tail Independent Non-canonical Translation to disrupt the viability of Primordial Germ Cells (PGCs) without affecting typical Polyadenylate Tail dependent translation mechanisms. This small molecule compound, discovered through chemical screening in zebrafish embryos, serves as a valuable tool for investigating translational control in various biological contexts. Researchers can utilize Primordazine B to explore gene expression regulation under conditions such as cellular dormancy, viral infection, or stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 339337-07-4 |
| Applications | PAINT Inhibitor |
| Formula | C18H17N5O2S |
| Molecular Weight | 367.42 |
| SMILES | O=C(CSC1=NN=C2C(N(C3=C2C=CC=C3)CC)=N1)NCC4=CC=CO4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.