PRLX-93936 is a molecular glue that targets the TRIM21 ubiquitin ligase to facilitate the degradation of nuclear pore complexes. By binding to TRIM21 and forming a ternary complex with TRIM21 and NUP98, this compound mediates ubiquitination and proteasomal degradation of NUP98 and related proteins. PRLX-93936 induces apoptosis in cancer cells, reduces the levels of short-lived cytoplasmic mRNA transcripts, and inhibits the activated Ras signaling pathway. It demonstrates significant antitumor activity in mouse models, particularly for pancreatic cancer and multiple myeloma, making it a valuable tool for cancer research.
PRLX-93936 is a molecular glue that targets the TRIM21 ubiquitin ligase to facilitate the degradation of nuclear pore complexes. By binding to TRIM21 and forming a ternary complex with TRIM21 and NUP98, this compound mediates ubiquitination and proteasomal degradation of NUP98 and related proteins. PRLX-93936 induces apoptosis in cancer cells, reduces the levels of short-lived cytoplasmic mRNA transcripts, and inhibits the activated Ras signaling pathway. It demonstrates significant antitumor activity in mouse models, particularly for pancreatic cancer and multiple myeloma, making it a valuable tool for cancer research.
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