PRMT5-MTA-IN-3-d3 is a deuterated form of the PRMT5-MTA inhibitor, designed for stable isotope applications. This compound exhibits notable antiproliferative activity against colorectal cancer cell lines, specifically showing IC50 values of 6 nM in MTAP-deficient HTC116-MTAP del cells and 961 nM in wild-type HCT-116 cells. PRMT5-MTA-IN-3-d3 is particularly relevant for research on cancers involving MTAP deficiency, including non-small cell lung cancer (NSCLC) and pancreatic cancer.
PRMT5-MTA-IN-3-d3 is a deuterated form of the PRMT5-MTA inhibitor, designed for stable isotope applications. This compound exhibits notable antiproliferative activity against colorectal cancer cell lines, specifically showing IC50 values of 6 nM in MTAP-deficient HTC116-MTAP del cells and 961 nM in wild-type HCT-116 cells. PRMT5-MTA-IN-3-d3 is particularly relevant for research on cancers involving MTAP deficiency, including non-small cell lung cancer (NSCLC) and pancreatic cancer.
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