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PRMT5-MTA-IN-3-d3

Stable Isotope

PRMT5-MTA-IN-3-d3 is a deuterated form of the PRMT5-MTA inhibitor, designed for stable isotope applications. This compound exhibits notable antiproliferative activity against colorectal cancer cell lines, specifically showing IC50 values of 6 nM in MTAP-deficient HTC116-MTAP del cells and 961 nM in wild-type HCT-116 cells. PRMT5-MTA-IN-3-d3 is particularly relevant for research on cancers involving MTAP deficiency, including non-small cell lung cancer (NSCLC) and pancreatic cancer.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3052146-54-7
Applications	Stable Isotope
Formula	C₁₉H₁₄D₃F₃N₆O₃
Molecular Weight	437.39
SMILES	CN1N=CC2=C1C(N)=NC=C2NC(C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C([2H])([2H])[2H])=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.