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Proadrenomedullin (N-20) (bovine, porcine)

Catecholamine Release Inhibitor

Proadrenomedullin (N-20) (bovine, porcine) is a potent noncompetitive inhibitor of catecholamine release, acting primarily on chromaffin cells. This peptide demonstrates significant hypotensive properties and inhibits catecholamine secretion with an IC50 of 350 nM in PC12 pheochromocytoma cells. Additionally, Proadrenomedullin (N-20) reduces desensitization of catecholamine release induced by nicotinic cholinergic agonists, with an EC50 of approximately 270 nM, thereby influencing nicotinic signal transduction pathways. This reagent is valuable for research into cardiovascular health and neuroendocrine responses.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	154095-31-5
Applications	Catecholamine Release Inhibitor
Formula	C₁₁₂H₁₇₈N₃₆O₂₆
Molecular Weight	2444.84
Synonyms	ProADM N20(bovine, porcine); PAMP-20(bovine, porcine)

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.