Procyanidin B2 3,3'-di-O-gallate is a selective Notch1 inhibitor that demonstrates significant biological activity against cancer stem cells, particularly in prostate cancer. This compound effectively targets both unsorted and sorted cancer stem cells at lower concentrations. By suppressing the activated Notch1 signaling pathway, including responses induced by the Jagged1 ligand, Procyanidin B2 3,3'-di-O-gallate is a valuable tool for research focused on cancer biology and therapeutic development.
Procyanidin B2 3,3'-di-O-gallate is a selective Notch1 inhibitor that demonstrates significant biological activity against cancer stem cells, particularly in prostate cancer. This compound effectively targets both unsorted and sorted cancer stem cells at lower concentrations. By suppressing the activated Notch1 signaling pathway, including responses induced by the Jagged1 ligand, Procyanidin B2 3,3'-di-O-gallate is a valuable tool for research focused on cancer biology and therapeutic development.
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