Fig. 1 · Structure
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Progerinin
progerin-lamin A binding inhibitor
Progerinin is a potent progerin-lamin A binding inhibitor that selectively targets the C-terminal region of progerin. By disrupting its interaction with lamin A, Progerinin promotes progerin degradation while sparing wild-type lamin proteins. This compound demonstrates significant biological activity by ameliorating nuclear deformation, enhancing H3K9me3 levels, and decreasing progerin expression in fibroblasts derived from HGPS patients. Furthermore, Progerinin has been shown to extend lifespan and improve various physiological parameters in LmnaG609G mouse models, making it a valuable tool for research into Hutchinson-Gilford progeria syndrome (HGPS).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2249696-72-6 |
| Applications | progerin-lamin A binding inhibitor |
| Formula | C23H22O4 |
| Molecular Weight | 362.42 |
| Synonyms | SLC-D011 |
| SMILES | CC1(OC2=CC(OC(C=C3)=O)=C3C=C2C[C@@H]1OC/C=C/C4=CC=CC=C4)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.