Fig. 1 · Structure
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Prostaglandin H2
Vasoconstrictor
Prostaglandin H2 (PGH2) serves as a potent vasoconstrictor primarily through its action as an endothelium-derived contracting factor. It is a crucial precursor for all prostaglandins and is synthesized by various cell types expressing cyclooxygenases. PGH2 activates PGD2 receptors, including CRTH2 and DP, either directly or via conversion to PGD2 by plasma proteins. Additionally, it promotes eosinophil migration, inhibits platelet aggregation, and facilitates the polymerization of amyloid β1-42 oligomers. Given its diverse biological activities, PGH2 is valuable for research into inflammation and neurodegenerative conditions, particularly Alzheimer's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 42935-17-1 |
| Applications | Vasoconstrictor |
| Formula | C20H32O5 |
| Molecular Weight | 352.47 |
| Synonyms | PGH2 |
| SMILES | CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@]2([H])C[C@@]1([H])OO2)C/C=C\CCCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.