Fig. 1 · Structure
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PROTAC Bcl-xL degrader-2
PROTAC Bcl-xL Degrader
PROTAC Bcl-xL Degrader-2 is a highly effective protein degrader targeting Bcl-xL, a member of the Bcl-2 family. Utilizing a von Hippel-Lindau ligand, this compound demonstrates a potent inhibition with an IC50 of 0.6 nM. It facilitates the selective degradation of Bcl-xL, making it a valuable tool for research in apoptotic processes and cancer therapy. Laboratory applications include studying the role of Bcl-xL in cell survival and investigating therapeutic strategies in Bcl-2-associated malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2920415-08-1 |
| Applications | PROTAC Bcl-xL Degrader |
| Formula | C68H80N8O14S3 |
| Molecular Weight | 1329.60 |
| SMILES | O=C(C1=C(CCCOC2=CC=C(C#CCOCCOCCOCCOCCOCCOCCC(N[C@H](C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)C=C2)SC(N6CC7=C(C=CC=C7C(NC8=NC9=CC=CC=C9S8)=O)CC6)=N1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.