PROTAC BET Degrader-16 is a potent BET PROTAC degrader specifically targeting BRD4 with a DC50 of 0.31 nM, displaying a strong selectivity for BRD4 over other BET family proteins. This compound facilitates the degradation of BRD2, BRD3, and BRD4 through the ubiquitin-proteasome system, utilizing CRBN E3 ligase recruitment. Research applications include the induction of cell cycle arrest and promotion of apoptosis, demonstrating anti-tumor effects particularly in acute myeloid leukemia.
PROTAC BET Degrader-16 is a potent BET PROTAC degrader specifically targeting BRD4 with a DC50 of 0.31 nM, displaying a strong selectivity for BRD4 over other BET family proteins. This compound facilitates the degradation of BRD2, BRD3, and BRD4 through the ubiquitin-proteasome system, utilizing CRBN E3 ligase recruitment. Research applications include the induction of cell cycle arrest and promotion of apoptosis, demonstrating anti-tumor effects particularly in acute myeloid leukemia.
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