Documents & Downloads

PROTAC BET Degrader-16

BET PROTAC Degrader

PROTAC BET Degrader-16 is a potent BET PROTAC degrader specifically targeting BRD4 with a DC50 of 0.31 nM, displaying a strong selectivity for BRD4 over other BET family proteins. This compound facilitates the degradation of BRD2, BRD3, and BRD4 through the ubiquitin-proteasome system, utilizing CRBN E3 ligase recruitment. Research applications include the induction of cell cycle arrest and promotion of apoptosis, demonstrating anti-tumor effects particularly in acute myeloid leukemia.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2410947-65-6
Applications	BET PROTAC Degrader
Formula	C₄₄H₄₅F₂N₇O₉S
Molecular Weight	885.93
SMILES	O=C(C(N1)=CC(C(C2=CC(NS(=O)(CC)=O)=CC=C2OC3=CC=C(F)C=C3F)=CN4C)=C1C4=O)NCCCCCCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.