Fig. 1 · Structure
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PROTAC BET degrader-3
PROTAC BET Degrader
PROTAC BET Degrader-3 is a PROTAC designed to target and degrade BET (bromodomain and extraterminal domain) proteins via the von Hippel-Lindau (VHL) E3 ligase pathway. This compound effectively facilitates the ubiquitination and subsequent proteasomal degradation of BET proteins, altering cellular signaling pathways. It is primarily utilized in research applications focused on cancer biology, epigenetics, and the exploration of therapeutic strategies for BET-related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3031993-61-7 |
| Applications | PROTAC BET Degrader |
| Formula | C53H64N12O9S |
| Molecular Weight | 1045.22 |
| SMILES | CCN1N=C(C2CC2)C=C1NC3=NC(C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=NC7=C3C8=CC(OC)=C(C(C(C)=NO9)=C9C)C=C8N7 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.