PROTAC BRD4 Degrader-14 is a targeted protein degradation compound designed to bind both von Hippel-Lindau (VHL) and the BRD4 protein. It demonstrates potent activity with IC50 values of 1.8 nM for BRD4 BD1 and 1.7 nM for BRD4 BD2. This reagent effectively induces degradation of BRD4 in PC3 prostate cancer cells, making it a valuable tool for studying BRD4-related pathways and potential therapeutic interventions in cancer research.
PROTAC BRD4 Degrader-14 is a targeted protein degradation compound designed to bind both von Hippel-Lindau (VHL) and the BRD4 protein. It demonstrates potent activity with IC50 values of 1.8 nM for BRD4 BD1 and 1.7 nM for BRD4 BD2. This reagent effectively induces degradation of BRD4 in PC3 prostate cancer cells, making it a valuable tool for studying BRD4-related pathways and potential therapeutic interventions in cancer research.
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