Fig. 1 · Structure
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PROTAC BRD4 Degrader-5-CO-PEG3-N3
PROTAC-Linker Conjugates for PAC
PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a PROTAC-linker conjugate designed for proteolysis-targeting chimera (PAC) applications, featuring the BRD4 degrader GNE-987 linked via a PEG-based moiety. This compound facilitates targeted protein degradation by utilizing a click chemistry framework, incorporating an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynylated molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds, making it a versatile tool for chemical biology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2704602-92-4 |
| Applications | PROTAC-Linker Conjugates for PAC |
| Formula | C58H75ClN12O12S2 |
| Molecular Weight | 1231.87 |
| SMILES | O=C(O[C@H]1CN(C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)=O)[C@H](C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)C1)COCCOCCOCCN=[N+]=[N-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.