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PROTAC BRD4 ligand-1-NH-PEG-phenol-PEG-COOtBu

Target Protein Ligand-Linker Conjugate

PROTAC BRD4 ligand-1-NH-PEG-phenol-PEG-COOtBu is a targeted protein ligand-linker conjugate designed for efficient degradation of BRD4. This compound features a specific ligand for BRD4 and a PROTAC linker, facilitating the recruitment of an E3 ubiquitin ligase to promote targeted protein degradation. It serves as a valuable tool for research applications focused on the modulation of BRD4-related pathways and the development of PROTAC-based therapeutic strategies, including the synthesis of PROTAC BRD4 Degrader-14.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2973054-19-0
Applications	Target Protein Ligand-Linker Conjugate
Formula	C₃₉H₄₁F₂N₅O₉S
Molecular Weight	793.83
SMILES	O=C(COCCC1=CC(OCCNC(C2=CC3=C(C4=CN(C)C(C5=C4C(CN3C6=NC=C(C=C6F)F)=CN5)=O)C=C2CS(=O)(C)=O)=O)=CC(O)=C1)OC(C)(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.