Documents & Downloads

PROTAC BRM/BRG1 degrader-1

PROTAC BRM/BRG1 Degrader

PROTAC BRM/BRG1 Degrader-1 is a targeted protein degradation agent designed to selectively degrade the BRM and BRG1 proteins, with a DC50 of 10-100 nM for BRM and greater than 1 μM for BRG1. This compound facilitates the study of chromatin remodeling complexes in cancer research, enabling the investigation of their roles in tumorigenesis and potential therapeutic strategies. The molecule is composed of an E3 ligase ligand, a linker, and a selective BRM/BRG1 inhibitor, allowing for precise modulation of protein levels in cellular systems.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2724268-88-4
Applications	PROTAC BRM/BRG1 Degrader
Formula	C₅₄H₆₃N₉O₉S
Molecular Weight	1014.20
SMILES	NC(N=NC(C1=C(O)C=CC=C1)=C2)=C2OCCC3=CC=C(C(N4CC(OC5CCN(CCOC6=NOC([C@@H](C(C)C)C(N7C[C@H](O)C[C@H]7C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)=C6)CC5)C4)=O)C=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.