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PROTAC BRM/BRG1 degrader-2

BRM/BRG1 Degrader

PROTAC BRM/BRG1 degrader-2 is a potent degrader specifically targeting the BRM/BRG1 proteins via the PROTAC mechanism. It exhibits a DC50 of less than 10 nM in A549 cells, with an IC50 of 15 nM, showcasing its effective biological activity in promoting proteolytic degradation. This compound serves as a valuable tool for researching the roles of BRM/BRG1 in cancer biology and other cellular processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2933124-32-2
Applications	BRM/BRG1 Degrader
Formula	C₅₀H₆₀N₁₂O₅S
Molecular Weight	941.15
SMILES	NC(C1=C2C=C(C3=C(O)C=CC=C3)N=N1)=NN2C(CC4)CCN4C5=NC=C([C@H]6CC[C@H](C(N[C@@H](C(C)(C)C)C(N7C[C@H](O)C[C@H]7C(N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C)=O)=O)=O)CC6)C=N5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.