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PROTAC BRM/BRG1 degrader-3

PROTACs-Based BRM/BRG1 Degrader

PROTAC BRM/BRG1 degrader-3 is a PROTAC-based degrader specifically targeting BRM and BRG1, demonstrating a DC50 value of less than 1 nM for BRM degradation and greater than 1 nM for BRG1 degradation in SW1573 cells. This compound exhibits significant anti-tumor and anti-proliferative activity against A549 cells, with an IC50 of 0.6 nM. Its potent mechanisms make it a valuable tool for investigating the roles of BRM and BRG1 in cancer biology and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2933125-05-2
Applications	PROTACs-Based BRM/BRG1 Degrader
Formula	C₅₀H₆₃N₁₁O₅S
Molecular Weight	930.17
SMILES	OC(C=CC=C1)=C1C2=CC3=C(N=N2)C(NC(C)C)=NN3C4CCN(CC5CCN(C6=NOC(C(C(N7C[C@H](O)C[C@H]7C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)C(C)C)=C6)CC5)CC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.