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PROTAC BRM degrader-1

BRM Degrader

PROTAC BRM degrader-1 is a PROTAC-based compound that selectively targets and degrades the BRM and BRG1 proteins, demonstrating DC50 values of 93 pM and 4.9 nM, respectively. This compound facilitates the targeted protein degradation pathway, making it a valuable tool in research aimed at understanding complex biological processes involving these ATP-dependent chromatin remodeling factors. Its application in cellular and molecular biology studies could provide insights into the roles of BRM and BRG1 in various diseases, including cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2378051-80-8
Applications	BRM Degrader
Formula	C₅₇H₆₉N₁₁O₈S
Molecular Weight	1068.29
SMILES	NC1=C(C=C(C(C=CC=C2)=C2O)N=N1)N3C[C@H](CC4)N(C5=CC=NC(O[C@@H](C6)C[C@H]6OC(CC7)CCN7CCOC8=NOC([C@@H](C(C)C)C(N(C[C@@H]9O)[C@@H](C9)C(N[C@H](C%10=CC=C(C(SC=N%11)=C%11C)C=C%10)C)=O)=O)=C8)=C5)[C@H]4C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.