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PROTAC BTK Degrader-9

Nuclear Factor of activated T Cells (NFAT) Inhibitor

PROTAC BTK Degrader-9 functions as a targeted degrader of Bruton's tyrosine kinase (BTK), primarily inhibiting the NFAT signaling pathway. By downregulating the BTK-PLCγ2-Ca2+-NFATc1 cascade activated by RANKL, it demonstrates significant potential in inhibiting osteoclastogenesis and reducing alveolar bone loss. This compound is suitable for research applications related to bone resorption and inflammation in models of periodontitis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3034024-77-3
Applications	Nuclear Factor of activated T Cells (NFAT) Inhibitor
Formula	C₄₆H₅₂FN₁₃O₅
Molecular Weight	885.99
SMILES	CC1=CC(C2=NC(NC3=CN(C4CCN(CC4)CC5CCN(C6=CC=C7C(C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=C6)CC5)N=C3)=NC=C2F)=CC=C1CNC(C9=CN(C(C)(C)C)N=N9)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.