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PROTAC Cbl-b-IN-1

Cbl-b PROTAC Degrader

PROTAC Cbl-b-IN-1 is a potent Cbl-b PROTAC degrader, exhibiting a DC50 of less than 30 nM. This compound effectively induces the targeted degradation of the Cbl-b protein, making it a valuable tool for cancer research. Its ability to modulate protein levels through degradation pathways allows for in-depth studies of Cbl-b's role in tumor biology and therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3035210-39-7
Applications	Cbl-b PROTAC Degrader
Formula	C₅₃H₆₅F₃N₁₂O₆
Molecular Weight	1023.16
SMILES	OC=O.FC(F)(C1=CC(CN2CCN(CC2)CCN3CCC(CC3)CN4CCN(C5=CC=C(C(N([C@@H]6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)=CN8C1=CN(C9=CC([C@H](C%10=NN=CN%10C)C%11CCC%11)=CC=C9)C8=O)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.