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PROTAC CBP/P300 Degrader-2

PROTAC

PROTAC CBP/P300 Degrader-2 is a PROTAC that targets the CBP and p300 proteins, promoting their degradation via the ubiquitin-proteasome system. This compound is effective in modulating gene transcription and can be utilized in research studies focused on cancer, autoimmune disorders, inflammatory conditions, and neurodegenerative diseases. Its potential to selectively degrade these co-activators makes it a valuable tool for investigating the therapeutic implications of targeting transcriptional regulation in various disease contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3102127-45-4
Applications	PROTAC
Formula	C₅₀H₄₉F₂N₇O₅
Molecular Weight	865.96
SMILES	CC(C(N(C1=C2)C)=O)=CC1=C(N3CCCC(C=C4C5=CN(C6CCN(C7=CC=C(C8=C7C=CC=C8C9=O)N9C%10CCC(NC%10=O)=O)CC6)N=C5)=C3C=C4C(F)F)C=C2C%11CCOCC%11

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.