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PROTAC CDK2 Degrader-1

PROTAC Degrader

PROTAC CDK2 Degrader-1 is a selective PROTAC degrader designed to target cyclin-dependent kinase 2 (CDK2). This compound effectively induces degradation of CDK2 and inhibits phosphorylation of the retinoblastoma (RB) protein in the CDK2-dependent OVCAR3 cell line, with an IC50 range of 100-500 nM. It serves as a valuable tool for investigating the biological functions of CDK2 in cancer research and therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3024971-78-3
Applications	PROTAC Degrader
Formula	C₃₈H₄₆F₆N₁₂O₄S
Molecular Weight	880.91
SMILES	CN1C2=CC(C3CCN(CC4CCN(S(N5CCC(NC6=NC(C7=CN(CC(F)(F)F)N=C7)=C(C(F)(F)F)C=N6)CC5)(=O)=O)CC4)CC3)=CC=C2C(N8CCC(NC8=O)=O)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.