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PROTAC CDK4/6/9 degrader 1

PROTAC CDK4/6/9 Degrader

PROTAC CDK4/6/9 Degrader 1 is a targeted protein degradation agent that specifically degrades cyclin-dependent kinases CDK4, CDK6, and CDK9. This compound effectively inhibits the proliferation of triple-negative breast cancer (TNBC) cells by inducing G1 phase arrest, promoting apoptosis, and suppressing cellular migration and invasion. PROTAC CDK4/6/9 Degrader 1 serves as a valuable tool for studying the role of these kinases in TNBC and may support the development of novel therapeutic strategies aimed at this aggressive cancer subtype.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3064994-97-1
Applications	PROTAC CDK4/6/9 Degrader
Formula	C₅₁H₆₂N₁₂O₇
Molecular Weight	955.11
SMILES	O=C(C1=CC2=C(N=C(N=C2)NC3=CC=C(C=C3)C(CN4CCN(CC4)CC5CCN(CC5)CC(N6CCN(CC6)C7=CC=C(C8=C7)C(N(C8=O)C9CCC(NC9=O)=O)=O)=O)=O)N1C%10CCCC%10)N(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.