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PROTAC CDK9 degrader-5

Catalog No.: A54441
CDK9 PROTAC
PROTAC CDK9 degrader-5 is a targeted PROTAC that specifically degrades CDK9 through the proteasomal pathway. It effectively induces degradation of CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively. This reagent is a valuable tool for investigating the role of CDK9 in various biological processes and for potential therapeutic applications in cancer research.
PROTAC CDK9 degrader-5 2935587-89-4 CDK9 PROTAC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC CDK9 degrader-5 is a targeted PROTAC that specifically degrades CDK9 through the proteasomal pathway. It effectively induces degradation of CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively. This reagent is a valuable tool for investigating the role of CDK9 in various biological processes and for potential therapeutic applications in cancer research.
Product Information
Catalog NumA54441
FormulaC42H48Cl2N8O9
Molecular Weight879.78
CAS Number2935587-89-4
SMILESO=C(NCCCCCCCCCCC(N1CCC(CC1)NC(C2=NNC=C2NC(C3=C(C=CC=C3Cl)Cl)=O)=O)=O)COC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O
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Cell Cycle > CDK