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PROTAC CDK9 degrader-6

CDK9 PROTAC

PROTAC CDK9 degrader-6 is a proteolysis-targeting chimera (PROTAC) designed to specifically target and degrade cyclin-dependent kinase 9 (CDK9) through the ubiquitin-proteasome system. This compound effectively induces the degradation of CDK9, exhibiting DC50 values of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively. It is useful in research applications investigating the modulation of transcriptional regulation and the therapeutic potential in cancers driven by aberrant CDK9 activity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2935587-91-8
Applications	CDK9 PROTAC
Formula	C₄₂H₄₉Cl₂N₉O₈
Molecular Weight	878.80
SMILES	O=C(NCCCCCCCCCCC(N1CCC(CC1)NC(C2=NNC=C2NC(C3=C(C=CC=C3Cl)Cl)=O)=O)=O)CNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.