Fig. 1 · Structure
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PROTAC EGFR degrader 11
EGFR PROTAC Degrader
PROTAC EGFR Degrader 11 is a targeted degrader specifically designed to modulate the epidermal growth factor receptor (EGFR) through the PROTAC mechanism. It effectively binds to the CRBN-DDB1 complex with a Ki value of 36 nM and has a DC50 of less than 100 nM for EGFR degradation. This compound demonstrates significant biological activity by degrading not only EGFR but also focal adhesion kinase (FAK) and RSK1. Additionally, it inhibits the proliferation of BaF3 cells with both wild-type and mutant EGFR variants, achieving an IC50 of less than 100 nM, making it a valuable tool for cancer research focused on EGFR-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3034244-71-5 |
| Applications | EGFR PROTAC Degrader |
| Formula | C49H64ClFN10O7S |
| Molecular Weight | 991.61 |
| SMILES | O=C1C(C2=C(F)C=C(N3CCC(OCCN(CC4)CCN4C(CC5)CCN5C(C(CC)=C6)=CC(OC)=C6NC7=NC=C(Cl)C(NC8=CC=C(OC)C=C8N(S(=O)(C)=O)C)=N7)CC3)C=C2)CCC(N1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.