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PROTAC EGFR degrader 16

EGFR PROTAC Degrader

PROTAC EGFR degrader 16 is a selective degrader designed to target the epidermal growth factor receptor (EGFR). It exhibits DC50 values of less than 50 nM in various cell lines, including NCI-H1975 (EGFR L858R-T970M), NCI-H3225 (EGFR L858R), and NCI-H1976 + CS (EGFR L858R-T970M-L797S). This compound is valuable for investigating EGFR-driven cancers, particularly non-small cell lung cancer, facilitating research into targeted degradation therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2654821-07-3
Applications	EGFR PROTAC Degrader
Formula	C₄₈H₄₈F₂N₁₀O₆S
Molecular Weight	931.02
SMILES	O=C(NC1=NC=CS1)C(C2=C(CCC3)N3C=N2)N(CC4=C5C=C(C6=CC=C(N(C7)CC87CN(C(CC9(O)CCN(C%10=CC=C(N[C@H](CC%11)C(NC%11=O)=O)C=C%10F)CC9)=O)C8)C=C6)C=C4F)C5=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.