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PROTAC EGFR degrader 17

EGFR PROTAC Degrader

PROTAC EGFR degrader 17 is a potent EGFR-targeted PROTAC degrader with a DC50 value of 0.49 nM. This reagent facilitates the ubiquitination and subsequent degradation of the epidermal growth factor receptor (EGFR). It is particularly useful for research applications related to various forms of cancer, including non-small cell lung cancer, providing a valuable tool for investigating targeted degradation pathways in oncogenesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3065209-64-2
Applications	EGFR PROTAC Degrader
Formula	C₄₆H₅₁N₁₁O₅
Molecular Weight	837.97
SMILES	CN1N=CC(C2=CC(C(/N=C3N(C4)C(C=C(N5CCN(CC6CN(C7=CC(CN(C8C(NC(CC8)=O)=O)C9=O)=C9C=C7)C6)CC5)C=C%10)=C%10N/3)=O)=CC(C)=N2)=C1OC[C@@H]%11C[C@H]4CC%11

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.