Fig. 1 · Structure
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PROTAC EGFR degrader 9
PROTAC EGFR Degrader
PROTAC EGFR Degrader 9 is a CRBN-based PROTAC designed to specifically target and degrade the mutant forms of the epidermal growth factor receptor (EGFR), particularly EGFRL858R/T790M/C797S. It demonstrates potent degradation activity with a DC50 of 10.2 nM and a Kd of 240.2 nM, effectively eliminating EGFR mutants while leaving wild-type EGFR unaffected. This compound serves as a valuable tool in cancer research, particularly in studies focused on targeted therapies for EGFR-driven malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2992670-33-2 |
| Applications | PROTAC EGFR Degrader |
| Formula | C45H48F3N9O6S |
| Molecular Weight | 899.98 |
| SMILES | O=C(CCCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C4=CN(C5=CC=CC=C54)S(=O)(CC)=O)=N3)C(F)(F)F)C=C2)CC1)NC6=CC=CC7=C6CN(C7=O)C8C(NC(CC8)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.