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PROTAC ERα Degrader-10

ERα Degrader

PROTAC ERα Degrader-10 (Compound 160a) is a potent degrader targeting estrogen receptor alpha (ERα) with a DC50 of 0.37-1.1 nM in cell lines such as MCF7, T47D, and CAMA-1. This compound effectively induces degradation of ERα, demonstrating significant antitumor activity in mouse models. It is a valuable tool for investigating ERα-related signaling pathways and exploring therapeutic strategies for ERα-positive breast cancers.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2421260-43-5
Applications	ERα Degrader
Formula	C₄₅H₄₉N₅O₄
Molecular Weight	723.90
SMILES	CC/C(C1=CC=CC=C1)=C(C2=CC=C(N3CCC(CN4CCN(C5=CC(CN([C@H]6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)CC3)C=C2)\C8=CC=C(O)C=C8

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.