Fig. 1 · Structure
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PROTAC(H-PGDS)-8
H-PGD PROTAC Degrader
PROTAC(H-PGDS)-8 is a targeted protein degradation compound that specifically degrades hematopoietic prostaglandin D synthase (H-PGDS) with an IC50 of 0.14 μM. This PROTAC molecule facilitates the ubiquitination and subsequent proteasomal degradation of H-PGDS, making it a valuable tool for investigating the role of H-PGDS in various biological processes. Research applications include studies on inflammation, pain mechanisms, and other pathophysiological conditions where H-PGDS is implicated.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2761281-51-8 |
| Applications | H-PGD PROTAC Degrader |
| Formula | C41H40N8O7 |
| Molecular Weight | 756.81 |
| SMILES | O=C(C1CCN(CC1)C2=CC=C(C=C2)NC(C3=CN=C(N=C3)OC4=CC=CC=C4)=O)N5CCN(CC5)C6=C(C7=CC=C6)C(N(C7=O)C8CCC(N(C8=O)C)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.