Fig. 1 · Structure
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PROTAC Her3 Degrader-8
Her3 PROTAC Degrader
PROTAC Her3 Degrader-8 is a potent Her3 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of the Her3 protein. This compound is particularly relevant for studies focused on lung adenocarcinoma and ovarian cancer, enabling researchers to investigate the role of Her3 in these malignancies. The design incorporates a specific Her3 ligand, an E3 ligase ligand, and a linker, which optimizes its efficacy as a targeted degradation tool in research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2103331-95-7 |
| Applications | Her3 PROTAC Degrader |
| Formula | C49H55N11O6S |
| Molecular Weight | 926.10 |
| SMILES | NC1=C2C(C(C=C3)=CC(NC(C=C)=O)=C3OC4=CC=CC=C4)=NN(C(CC5)CCN5CC(N[C@H](C(C)(C)C)C(N(C[C@H]6O)[C@H](C6)C(NCC7=CC=C(C(SC=N8)=C8C)C=C7)=O)=O)=O)C2=NC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.