Documents & Downloads

PROTAC HMGCR Degrader-1

PROTAC

PROTAC HMGCR Degrader-1 is an orally active PROTAC targeting HMGCR, exhibiting an IC50 of 1.32 μM. This lactone prodrug effectively leads to significant degradation of HMGCR, resulting in substantial cholesterol-lowering effects observed in vivo. PROTAC HMGCR Degrader-1 is valuable for research applications focused on hyperlipidemia and lipid metabolism.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2715104-45-1
Applications	PROTAC
Formula	C₅₃H₇₇N₅O₉S
Molecular Weight	960.27
SMILES	O=C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.