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PROTAC HPK1 Degrader-2

PROTAC HPK1 Degrader

PROTAC HPK1 Degrader-2 targets HPK1 for degradation via a proteolysis-targeting chimera (PROTAC) mechanism. With a DC50 of 23 nM in human peripheral blood mononuclear cells (PBMC), this compound is instrumental in elucidating HPK1's functions in cancer biology. The selectivity and potency of PROTAC HPK1 Degrader-2 make it a valuable tool for cancer research applications, enabling the study of targeted protein degradation and its implications in therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2893885-31-7
Applications	PROTAC HPK1 Degrader
Formula	C₄₃H₄₇N₉O₄
Molecular Weight	753.89
SMILES	CC1=C2C(CCN(CCC(N3CCN(C4=CC=C(N5C(NC(CC5)=O)=O)C=C4)CC3)=O)C2)=CC(C6=NC(C(C7=CC=C(C(N(C)C)=O)C(C)=C7)=CN8)=C8N=C6)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.