Fig. 1 · Structure
Documents & Downloads
PROTAC JAK1 degrader 1
JAK1 PROTAC Degrader
PROTAC JAK1 Degrader 1 is a selective PROTAC agent targeting JAK1, exhibiting a DC50 of 214 nM. This compound initiates rapid degradation of JAK1, leading to significant antitumor activity. It serves as a valuable tool for investigating JAK1-related signaling pathways and developing therapeutic strategies for malignancies driven by JAK1 dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3052553-20-2 |
| Applications | JAK1 PROTAC Degrader |
| Formula | C44H41N9O6 |
| Molecular Weight | 791.85 |
| SMILES | O=C(NCC#N)C1=CC=C(C2=NC(NC3=CC=C(N4CCC(C(NCCCCC#CC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)CC4)C=C3)=NC=C2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.