Fig. 1 · Structure
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PROTAC K-Ras Degrader-1
PROTAC K-Ras Degrader
PROTAC K-Ras Degrader-1 (Compound 518) is a cereblon-based PROTAC that selectively degrades K-Ras, achieving ≥70% degradation efficiency in SW1573 cells. It serves as a valuable tool for studying K-Ras-driven signaling pathways and potential therapeutic strategies in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2378258-52-5 |
| Applications | PROTAC K-Ras Degrader |
| Formula | C53H62N10O10 |
| Molecular Weight | 999.12 |
| SMILES | O(C[C@@H]1C[C@@H](OCCOCCOCCOCCNC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)CN1C)C5=NC(=C6C(CN(CC6)C=7C8=C(C=CC7)C=CC=C8)=N5)N9C[C@H](CC#N)N(C(C=C)=O)CC9 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.