Fig. 1 · Structure
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PROTAC K-Ras Degrader-2
PROTAC K-Ras Degrader
PROTAC K-Ras Degrader-2 is a selective PROTAC degrader designed to target pan-KRAS mutants, exhibiting an IC50 of ≤200 nM against KRAS G12V and RAF1. This compound effectively degrades KRAS G12D in SW620 cells with a DC50 of ≤200 nM and inhibits cell growth in 3D cultures at an IC50 of ≤20 nM. PROTAC K-Ras Degrader-2 is a valuable tool for investigating therapeutic strategies in colorectal cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3043670-74-9 |
| Applications | PROTAC K-Ras Degrader |
| Formula | C52H60F4N8O5 |
| Molecular Weight | 953.08 |
| SMILES | FC1=C(C2=CC(O)=CC3=C2C(CC)=C(F)C=C3)N=CC4=C1N=C(N=C4N5C[C@](O)(CCC5)C)OCC6(CC6)CN7CCC(C)(CC7)CN8CCN(C9=CC(F)=C(C%10C(NC(CC%10)=O)=O)C(F)=C9)CC8 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.