PROTAC K-Ras Degrader-3 is a powerful PROTAC compound designed to target and degrade K-Ras, demonstrating a DC50 of ≤ 1 nM in SW620 KRAS G12D cells and a GI50 of ≤ 10 nM for inhibiting SW620 3D cell growth. This compound is particularly valuable in cancer research, especially for studying non-small-cell lung cancer (NSCLC). Its unique design incorporates a K-RAS ligand, a Cereblon ligand, and a linker, facilitating targeted degradation and offering insights into K-Ras-related pathways.
PROTAC K-Ras Degrader-3 is a powerful PROTAC compound designed to target and degrade K-Ras, demonstrating a DC50 of ≤ 1 nM in SW620 KRAS G12D cells and a GI50 of ≤ 10 nM for inhibiting SW620 3D cell growth. This compound is particularly valuable in cancer research, especially for studying non-small-cell lung cancer (NSCLC). Its unique design incorporates a K-RAS ligand, a Cereblon ligand, and a linker, facilitating targeted degradation and offering insights into K-Ras-related pathways.
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