Fig. 1 · Structure
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PROTAC K-Ras Degrader-4
PROTAC K-Ras Degrader
PROTAC K-Ras Degrader-4 specifically targets and degrades mutant KRAS proteins, including KRASG12D and KRASG12V, with DC50 values of 1 nM and 13 nM, respectively. By inhibiting the MAPK signaling pathway, this compound serves as a powerful tool for studying the functional implications of KRAS mutations in cancer biology. Research applications include elucidating the role of KRAS in tumorigenesis and evaluating the therapeutic potential of targeting this oncogene in various malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2938169-99-2 |
| Applications | PROTAC K-Ras Degrader |
| Formula | C50H60N12O6S2 |
| Molecular Weight | 989.22 |
| SMILES | C[C@@]1(C2=NC(C3=NC(N4[C@H](CN(CCC4)CCCCOC5=NOC([C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=C5)C)=NC=C3)=NO2)C9=C(CCC1)SC(N)=C9C#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.