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PROTAC K-Ras Degrader-6

KRAS PROTAC Degrader

PROTAC K-Ras Degrader-6 is a cereblon-based KRAS PROTAC degrader that effectively targets and promotes the degradation of KRAS proteins. With a DC50 of ≤100 nM, it exhibits significant anticancer activity, making it a valuable tool for research in cancer biology. This compound is particularly relevant for studies focusing on KRAS-driven malignancies and the development of targeted therapies that leverage the ubiquitin-proteasome system.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3052745-46-4
Applications	KRAS PROTAC Degrader
Formula	C₅₇H₆₅F₂N₁₁O₅
Molecular Weight	1022.19
SMILES	C#CC1=C(C=CC2=CC(O)=CC(C3=NC=C4C(N5CC6CCC(N6)C5)=NC(OCCN7CCC(CC7)CC8CCN(CC8)CC9CCN(CC9)C%10=CC%11=C(N(C(N%11C)=O)C%12CCC(NC%12=O)=O)C=C%10)=NC4=C3F)=C21)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.