PROTAC K-Ras Degrader-6

Catalog No.: A63721
KRAS PROTAC Degrader
PROTAC K-Ras Degrader-6 is a cereblon-based KRAS PROTAC degrader that effectively targets and promotes the degradation of KRAS proteins. With a DC50 of ≤100 nM, it exhibits significant anticancer activity, making it a valuable tool for research in cancer biology. This compound is particularly relevant for studies focusing on KRAS-driven malignancies and the development of targeted therapies that leverage the ubiquitin-proteasome system.
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Size Stock
5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC K-Ras Degrader-6 is a cereblon-based KRAS PROTAC degrader that effectively targets and promotes the degradation of KRAS proteins. With a DC50 of ≤100 nM, it exhibits significant anticancer activity, making it a valuable tool for research in cancer biology. This compound is particularly relevant for studies focusing on KRAS-driven malignancies and the development of targeted therapies that leverage the ubiquitin-proteasome system.
Product Information
Catalog NumA63721
FormulaC57H65F2N11O5
Molecular Weight1022.19
CAS Number3052745-46-4
SMILESC#CC1=C(C=CC2=CC(O)=CC(C3=NC=C4C(N5CC6CCC(N6)C5)=NC(OCCN7CCC(CC7)CC8CCN(CC8)CC9CCN(CC9)C%10=CC%11=C(N(C(N%11C)=O)C%12CCC(NC%12=O)=O)C=C%10)=NC4=C3F)=C21)F
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