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PROTAC KSP degrader 1

KSP Degrader

PROTAC KSP Degrader 1 is a targeted protein degrader designed to selectively deplete kinesin spindle protein (KSP). This compound achieves a DC50 value of 114.8 nM for KSP degradation in HCT-116 cells and demonstrates a potent anti-proliferative effect with an IC50 of 10 nM. It effectively induces G2/M cell cycle arrest and triggers apoptosis in HCT-116 cells, exhibiting notable anti-tumor efficacy in relevant mouse models. This reagent serves as a valuable tool for investigating KSP's role in cancer biology and therapeutic approaches.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3099825-86-9
Applications	KSP Degrader
Formula	C₄₈H₅₁N₅O₈S
Molecular Weight	858.01
SMILES	O=C(NCCCCCCCCNC(COC1=C2C(C(N(C3CCC(NC3=O)=O)C2=O)=O)=CC=C1)=O)[C@@H](N)CSC4(C5=CC=C(OC)C=C5)C6=CC=CC=C6C=CC7=C4C=CC=C7

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.