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PROTAC LZK degrader 1

PROTAC

PROTAC LZK Degrader 1 is a potent PROTAC that selectively induces the degradation of Leucine Zipper Kinase (LZK), encoded by MAP3K13. This compound effectively downregulates the expression of key oncogenes such as p53 and c-MYC, resulting in decreased viability of head and neck squamous cell carcinoma (HNSCC) cell lines. PROTAC LZK Degrader 1 is a valuable tool for studying cancer biology and therapeutic strategies targeting LZK. The compound consists of an E3 ligase ligand, a target protein ligand, and a linker, facilitating the targeted degradation mechanism.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2763268-64-8
Applications	PROTAC
Formula	C₅₁H₆₄F₂N₁₀O₅S
Molecular Weight	967.18
SMILES	FC(CC1)(F)CN1C2=CC(C3CCN(C(CCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@@H](O)C4)=O)=O)=O)CC3)=CC(NC7=CC(C#N)=CC=N7)=N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.