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PROTAC MLKL Degrader-2

PROTAC

PROTAC MLKL Degrader-2 is a novel PROTAC designed to specifically target MLKL (Mixed Lineage Kinase) for degradation. This compound utilizes a bifunctional approach, combining an E3 ligase ligand, Thalidomide, with a linker, N-Methylpiperazine, to facilitate the ubiquitination and subsequent proteasomal degradation of MLKL. By effectively modulating MLKL levels, this reagent serves as a powerful tool for investigating the role of MLKL in various biological processes, including cell death and inflammatory responses, thus enabling insights into therapeutic interventions for related diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3103327-20-1
Applications	PROTAC
Formula	C₃₆H₃₅N₉O₉S
Molecular Weight	769.78
SMILES	O=C(NC1=CC=CC(C#CCN(C(N(C2=O)C)=O)C3=C2N(C(S(C)(=O)=O)=N3)C)=C1)CN4CCN(C5=CC6=C(C=C5)C(N(C6=O)C7CCC(NC7=O)=O)=O)CC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.