PROTAC pan-KRAS degrader-1 targets pan-KRAS mutations, facilitating the degradation of various KRAS variants, including G12D, G12C, G12V, and G13D. This compound exhibits potent activity against the G12D mutation in AGS cells, achieving a DC50 of 1.1 nM and a maximum degradation efficacy (Dmax) of 95%. PROTAC pan-KRAS degrader-1 is a valuable tool for investigating diseases associated with KRAS mutations and amplifications, particularly in cancer types such as breast, bladder, and gastric cancer.
PROTAC pan-KRAS degrader-1 targets pan-KRAS mutations, facilitating the degradation of various KRAS variants, including G12D, G12C, G12V, and G13D. This compound exhibits potent activity against the G12D mutation in AGS cells, achieving a DC50 of 1.1 nM and a maximum degradation efficacy (Dmax) of 95%. PROTAC pan-KRAS degrader-1 is a valuable tool for investigating diseases associated with KRAS mutations and amplifications, particularly in cancer types such as breast, bladder, and gastric cancer.
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