Fig. 1 · Structure
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PROTAC PIN1 degrader-1
PROTAC
PROTAC PIN1 degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to selectively degrade the prolyl isomerase PIN1, exhibiting a DC50 value of 1.8 nM. This compound demonstrates significant activity against the MDA-MB-468 cell line, with a GI50 > 30 μM. PROTAC PIN1 degrader-1 is structurally composed of the PIN1 ligand, an E3 ligase ligand derived from Thalidomide, and a PROTAC linker, enabling targeted degradation of PIN1 for potential therapeutic applications in cancer research and beyond.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3038591-59-9 |
| Applications | PROTAC |
| Formula | C51H52N10O7 |
| Molecular Weight | 917.02 |
| SMILES | CC1=CC=CN=C1C2(CC2)C(NC(CC(N=N3)=CN3C(C=C4)=CC=C4C(C=C5)=CC=C5C#N)C(NC(CC6)CCN6CCCCCOC7=CC=CC(C8=O)=C7C(N8C(CC9)C(NC9=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.