PROTAC RET Degrader 1 is an orally bioavailable RET PROTAC degrader that effectively crosses the blood-brain barrier. It demonstrates remarkable potency with DC50 values for various RET mutations, including 1.7 nM for RET (WT) and 3 nM for RET (G810S). PROTAC RET Degrader 1 exhibits strong anti-proliferative effects in cancer cell lines harboring oncogenic RET fusions and mutations, and shows significant anti-tumor efficacy in patient-derived xenograft mouse models. This reagent is valuable for investigating RET-positive cancers and their therapeutic targeting.
PROTAC RET Degrader 1 is an orally bioavailable RET PROTAC degrader that effectively crosses the blood-brain barrier. It demonstrates remarkable potency with DC50 values for various RET mutations, including 1.7 nM for RET (WT) and 3 nM for RET (G810S). PROTAC RET Degrader 1 exhibits strong anti-proliferative effects in cancer cell lines harboring oncogenic RET fusions and mutations, and shows significant anti-tumor efficacy in patient-derived xenograft mouse models. This reagent is valuable for investigating RET-positive cancers and their therapeutic targeting.
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